This book explores the history of the Nkwerre Isu Igbo (Isu Ama and Isu Ofe Iyi Igbo) groups of southeastern Nigeria. It deals with forces that shaped their cultural, social and political transformation. The book explores the mythology of the origin of the Isu clan and provides an overview of the people’s customs, traditions and their social and political organizations. Additionally, the book explores the role of Isu traders, travelling blacksmiths and medicine men and the emergence of the concepts of Isu fraternity and Isu guild of blacksmiths which laid sold foundation for Isu confederation as well as the pre-colonial stigma—Isuma, meaning nomads. The book reveals that the migration and settlement of Isu people outside the primary centre paint vivid pictures of hegemony, fraternity as articulated in the concept of Isu wu otu or universal brotherhood of Isu groups. Their history, however, like that of other Igbo societies was affected by British colonial administration and the divide and rule principle of administration. The transition of the Isu from tradition to modernity was influenced by exposure to western education, the native court system, mission churches. These changes had devastating effects on the traditional institutions, norms and values of the people. Consequently, the social and economic foundation of Isu people fell to the dictates of Europeanization with attendant ills such as the decline of moral values and increase in crimes. Church propaganda among other forms of structural changes has forced the Isu communities to succumb to change and modernization.